Search results for: tumor-suppressor-genes

Tumor Suppressor Genes in Human Cancer

Author : David E. Fisher
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David Fisher, MD, PhD, and an authoritative panel of academic, cutting-edge researchers review and summarize the current state of the field. Describing the broad roles of tumor suppressors from a perspective based in molecular biology and genetics, the authors detail the major suppressors and the pathways they regulate, including cell cycle progression, stress responses, apoptosis, and responses to DNA damage. Leading-edge and forward-looking, Tumor Suppressor Genes in Human Cancer illuminates what is currently known of tumor suppressor genes and their regulation, work that is already beginning to revolutionize cancer target elucidation, drug discovery, and treatment design.

Tumor Suppressor Genes

Author : Mehmet Gunduz
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Cancer is a devastating disease lacking an exact treatment. Recent advances in genetics and biotechnology have provided a deeper understanding of cancer biology, out of which aberrations in oncogenes and tumor suppressor genes have arisen as important etiological factors. Inactivation of tumor suppressor genes is one of the initial cellular changes that ultimately lead to tumor development. Thus, increasing knowledge about these genes aids in the development of novel therapeutic applications as well as identification of more effective and rapid molecular markers for early diagnosis and prognostic evaluation. This book provides up-to-date information on the structure, function and roles of the main tumor suppressor genes thus far identified. An important addition to the current literature in the field, this book is intended to help instructors for teaching purposes and researchers in the field of cancer biology as an overview of current knowledge.

Oncogenes and Tumor Suppressor Genes in Small Cell Lung Carcinoma

Author : Pankaj Taneja
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Oncogenes and Tumor Suppressor Genes in Small Cell Lung Carcinoma.

Tumor Suppressor Genes

Author : Klein George Ed
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These dozen articles treat a category of genes described as antioncogenes, tumor suppressor genes, or emerogenes, which can antagonize tumorigenic behavior at various levels. The four mechanisms or processes of tumor suppression discussed are the somatic hybridization of normal and malignant cells, physiological or chemical differentiation that down-regulates oncoprotein expression, the overriding of oncogenes by cellular genes as revertants, and the loss or mutational inactivation of "recessive cancer genes". Annotation(c) 2003 Book News, Inc., Portland, OR (booknews.com)

Tumor Suppressor Genes in the Pathogenesis of Prostate Cancer

Author : Suzana Sturlini Couto
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Inhibition of Angiogenesis Controlled by Tumor Suppressor Genes Thrombospondin 1 and Its Derived Peptides

Author : Sara Sybesma Tolsma
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Evaluation of the Tumor Suppressor Genes 14 3 3 Sigma and P53 in Feline Mammary Carcinoma

Author : Megan Strohmeyer Albertelli
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Investigation of Tumor Suppressor Genes on Human Chromosomes by Microcell Mediated Chromosome Transfer

Author : Karin G. Klein
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Tumor Suppressor Genes

Author : Katherine R. Polinsky
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A tumour suppressor gene is a gene that reduces the probability that a cell in a multicellular organism will turn into a tumor cell. A mutation or deletion of such a gene will increase the probability of the formation of a tumor. Unlike oncogenes, tumor suppressor genes generally follow the 'two-hit hypothesis', which implies that both alleles that code for a particular gene must be affected before an effect is manifested. This is due to the fact that if only one allele for the gene is damaged, the second can still produce the correct protein. However, there are cases where mutations in only one allele will cause an effect. A notable example is the gene that codes for p53. Tumor suppressor genes, or more precisely, the proteins for which they code, either have a dampening or repressive effect on the regulation of the cell cycle or promote apoptosis, and sometimes do both. This book presents new and important research from throughout the world.

Tumor Suppressor Genes

Author : Wafik S. El-Deiry
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Diagnostic and Therapeutic Advances in Pediatric Oncology

Author : David O. Walterhouse
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The purpose of Diagnostic and Therapeutic Advances in Pediatric Oncology for the Cancer Treatment and Research Series is to provide an up-to-date summary of how recent advances in cancer research are being applied to the care of children with solid tumors. The interface of cancer research with clinical practice in pediatric oncology has never been more intimate than today. While researchers are identifying oncogenes and tumor suppressor genes and are studying their specific functions, clinicians are using knowledge of oncogenes and tumor suppressor genes for diagnosing cancer in children, for therapeutic decision-making purposes, and for prognostic purposes. The first three chapters in this book describe models for understanding the causes of childhood cancer that were perhaps initially identified by clinicians and that are now being studied and understood by researchers. These chapters will describe research evidence that supports roles for the involvement of normal developmental regulatory genes in childhood oncogenesis, of abnormal immune regulation in childhood oncogenesis, and of heredity in childhood oncogenesis. The next eight chapters are devoted to descriptions of the appli cation of new research developments to clinical practice with reference to the most common forms of solid tumors of childhood outside the central nervous system. The final chapter will describe late effects of childhood cancer and its therapy and the impact research is having on understanding and perhaps preventing these late effects.

Journal of the National Cancer Institute

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Molecular Biology of Cancer

Author : Fiona Macdonald
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Molecular Biology of Cancer has been extensively revised and covers heredity cancer, microarray technology and increased study of childhood cancers. It continues to provide a detailed overview of the process which lead to the development and proliferation of cancer cells, including the techniques available for their study. It also describes the means by which tumor suppressor genes and oncogenes may be used in the diagnosis and in determining the prognosis of a wide variety of cancers, including breast, genitourinary, lung and gastrointestinal cancer.

Tumor Suppressor Gene Regulation of an Inhibitor of Angiogenesis

Author : Deborah Jean Good
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Tumor Suppressors

Author : John W. Ludlow
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Regulation of the Angiogenic Phenotype by the P53 Tumor Suppressor Gene

Author : Kristina Marie Dameron
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The Oncogene and Tumour Suppressor Gene Factsbook

Author : Robin Hesketh
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The Second Edition of The Oncogene and Tumour Suppressor Gene FactsBook has been completely revised, updated, and expanded by 60%. The book contains more than 80 entries on oncogenes including JUN, MYC, and RAS, as well as DNA tumour viruses, tumour suppressor genes, including p53, retinoblastoma, BRCA1, BRCA2, VHL, F2FL, and essential material on angiogenesis and metastasis, apoptosis, cell cycle control, and gene therapy. Includes much new data on this fast-moving field, including newly discovered oncogenes Summarizes the clinical association and molecular properties of all known oncogenes and tumor suppression genes Contains more than 2000 terms for reference and further research Revised to included signaling pathways, apoptosis, and metastasis

Immunohistochemical Evaluation of Human P53 Tumor Suppressor Protein Content in Ductal Carcinoma in Situ DCIS of the Breast

Author : Mehri Aliasgharpour
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Introduction to Oncogenes and Molecular Cancer Medicine

Author : Dennis W. Ross
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Providing the physician with a solid understanding of molecular biology and its applications for the diagnosis and treatment of cancer, this book reviews the basic molecular and other principles of cancer medicine, including controls of cell growth and senescence, carcinogenesis, tumorogenesis, and epidemiology. The second part of the book gives clinical examples to demonstrate the basic science principles, including chapters on leukaemia, colon cancer, and breast cancer. A chapter on molecular diagnostics and screening plus a chapter on new molecular anti-cancer therapies allow readers an insight into current therapies as well as the future of molecular cancer medicine. A useful glossary defines new terminology at-a-glance. Written in a user-friendly, conversational format, this text will be welcomed by all physicians eager to sharpen their own understanding of molecular cancer medicine as well as to help them provide patients with balanced information on the advances and limitations of current treatment options.

Cambridge Scientific Biochemistry Abstracts

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